Single-prolonged stress induces apoptosis in dorsal raphe nucleus in the rat model of posttraumatic stress disorder
نویسندگان
چکیده
منابع مشابه
Single-prolonged stress induces apoptosis in dorsal raphe nucleus in the rat model of posttraumatic stress disorder
INTRODUCTION Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after exposure to a life-threatening traumatic experience. Meta-analyses of the brainstem showed that midsagittal area of the pons was significantly reduced in patients with PTSD, suggesting a potential apoptosis in dorsal raphe nucleus after single-prolonged stress (SPS). The aim of this study is to investi...
متن کاملSingle-Prolonged Stress Induces Endoplasmic Reticulum - Dependent Apoptosis in the Hippocampus in a Rat Model of Post-Traumatic Stress Disorder
BACKGROUND Our previous research indicated that apoptosis induced atrophy in the hippocampus of post-traumatic stress disorder (PTSD) rats. Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in the development of several disorder diseases. The aim of this study was to investigate whether endoplasmic reticulum-related pathway is involved in single-prolonged stress (SPS) indu...
متن کاملSingle-prolonged stress induces apoptosis in the amygdala in a rat model of post-traumatic stress disorder.
OBJECTIVE To detect the apoptosis-related Bax and Bcl-2 gene expression and apoptotic cell death in the amygdala region in the single-prolonged stress (SPS) rats. METHODS A total of 100 male Wistar rats were randomly divided into a normal control group and SPS groups of 1d, 4d, 7d, and 14d. The expression of Bax and Bcl-2 was detected using immunohistochemistry and Western Blotting; TUNEL-sta...
متن کاملSingle prolonged stress induces dysfunction of endoplasmic reticulum in a rat model of post-traumatic stress disorder.
The aim of the present study, was to investigate the involvement of the endoplasmic reticulum (ER) in post-traumatic stress disorder (PTSD) by detecting changes of ER chaperone protein 78 and ER-resident caspase 12 in the basolateral amygdala after exposure to single prolonged stress (SPS). The established rat model of PTSD was generated by exposure of the animals to SPS. The expression of gluc...
متن کاملSingle-prolonged stress induces increased phosphorylation of extracellular signal-regulated kinase in a rat model of post-traumatic stress disorder.
The extracellular signal-regulated kinase (ERK) signaling transduction pathway has been implicated in multiple physiological processes. It is not clear whether the ERK1/2 pathway participates in post-traumatic stress disorder (PTSD). The aim of this study was to provide novel insights into the mechanisms of how the amygdala participates in PTSD by investigating changes in the ERK1/2 pathway ind...
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ژورنال
عنوان ژورنال: BMC Psychiatry
سال: 2012
ISSN: 1471-244X
DOI: 10.1186/1471-244x-12-211